Saturday, March 8, 2008

HIGH NOON




Larimer County is at the center of the battle over medical marijuana

James and Lisa Masters were getting ready to take their daughters fishing on the morning of Aug. 2, 2006, when two social workers and two police officers knocked on their door.

"We were just finishing folding laundry, getting ready for the day," says James, "and we had just recently medicated."

They had picked a bad time to take their medicine. The Masters are both medical marijuana patients, whose doctors recommend they get high to treat various physical and neurological illnesses.

The social workers raised allegations of child abuse and neglect toward their daughters, ages 4 and 6. The police officers, who the Masters were told came along in case the parents got violent - maybe in a fit of reefer madness - smelled the weed.

Inside, the Masters had 18 marijuana plant clones and an imminent harvest of 12 two-foot-high, bud-laden plants, which they say was for people suffering from glaucoma, cancer, HIV, multiple sclerosis and other crippling diseases.

The Masters' home was serving as the county chapter of the Colorado Compassion Club, a statewide network that provides quality weed for medical marijuana patients, including themselves. Despite having doctors' recommendations for the medicinal crop as allowed through a state constitutional amendment, the Larimer County Drug Task Force snagged the pot - and child protection services snagged the Masters' daughters, who were separated from their parents for nearly two months.

"They came here with the understanding that we were medical [marijuana] patients," says James. "There's no reason that two happy, well-adjusted girls should ever be taken away from their family because of cannabis."

James and Lisa, now reunited with their daughters, are facing criminal charges for distributing a controlled substance. The bust raises all of the usual questions about the misplaced priorities of the War on Drugs. But, even more, the Masters' upcoming trial, scheduled for June 4 at the Larimer County Courthouse, is being called a "test case" for the rights of medical marijuana patients and caregivers.

The outcome could affect how Colorado regulates the cultivation, distribution and sale of the drug for medicinal use. Ultimately, the Masters' trial could lead to an expansion of the state's medical marijuana program and a wider acceptance of pot as a healing remedy instead of just another way to get stoned.

The Compassion Club
James doesn't know exactly what's wrong with his body. He might have porphyria - an enzyme abnormality - or an overstock supply of hepatitis antibodies, although he's never had the disease or a vaccination. What the Fort Collins native does know is that, "since the age of 23, I've been throwing up every day," he says.

He suffers from constant nausea, stomach cramps, muscle spasms and swelling. James is 29 years old and walks with a cane. In the first year of his illness, he fell into a coma. Later, incontinence kept him from holding down jobs or attending college, and he suffered from depression, unable to provide for his young family. The doctors prescribed him a lineup of pharmaceutical narcotics, including diazepam, hydromorphone and antidepressant and antipsychotic drugs.

"For the first three or four years of my marriage, I had a living corpse on my floor," says Lisa. "They had him on 11 medications at one point."

Lisa, 31, has her own list of physical maladies. Three protruding discs in her neck, two of which are possibly herniated. Joint swelling and muscle spasms. Carpal tunnel syndrome in both wrists. Bursitis in both ankles.

Marijuana, the Masters say, provides relief from their sicknesses, numbing muscle and nerve pain and nausea.

"Symptomatically, I noticed I had less episodes when I was smoking," says James, "but, at that point [in 2001], I had kids and I couldn't afford marijuana."

In 2000, James remembers when the state passed a medical marijuana law, but he says it meant "absolutely nothing" at the time because there was so little information about the program. When he asked his family physician to refer him, the doctor refused to help and even failed to tell James about the state health department website for potential patients.

Colorado voters passed Amendment 20 in 2000, which allows doctor-recommended patients with debilitating diseases to smoke pot and hold up to two ounces, or six plants (with three or fewer being mature, flowering plants), of marijuana. Under the constitutional amendment, medical marijuana users are supposed to register with the state.

In January 2006, citizens in Gunnison County decided in favor of medical marijuana user Ryan Margenau. The jury held that, according to Amendment 20, a patient doesn't need to be registered, but does require a recommendation from a Colorado doctor.

"Patients don't have to go through every single step to be legal. They can just have a doctor's recommendation, and it's worth noting that the doctor's recommendation can be oral or written," says Brian Vicente, one of two attorneys representing the Masters and executive director of Sensible Colorado, a nonprofit group that works on behalf of medical marijuana users and supports pot decriminalization.

The staff of Colorado's Medical Marijuana Registry approves applications but does not issue licenses or permits. The state won't connect potential patients with doctors who will recommend pot for treatment, does not share information on how to acquire or grow weed, and does not recognize patients who have been approved for medical mari-juana use in other states.

Through another friend, the Masters met Thomas and Larisa Lawrence, a Denver couple, in 2003. Thomas Lawrence is a registered medical marijuana user, and he and his wife had begun serving as caregivers, maintaining a garden of high-quality pot for other patients. They shared information about doctors who would consider recommending people for treatment. The Lawrences eventually created the Colorado Compassion Club in 2004 to run a marijuana dispensary for patients, who donated money for pot, seeds or clippings.

The Masters first received doctors' recommendations in the summer of 2004, and they began coordinating with the Lawrences to help distribute pot to patients in Northern Colorado. Lisa cooks and bakes with ganja, providing meals for patients with throat illnesses or those who have never smoked. (She says her daughters know the couple smokes and grows pot for other sick people, but claims they never smoke in front of the girls and they've kept their plants and drugs in a locked study.)

Last May, James began organizing weekly gatherings to spread the word about how to enroll for medical marijuana privilidges, ultimately opening the Larimer County chapter of the Compassion Club.

"I started holding meetings," says James, "and what I heard over and over again from people with cancer, HIV, full-blown AIDS, was, ‘Where do I get medicine?'"

The Masters started their own garden for Compassion Club patients last summer. Their first homegrown crop consisted of the 12 mature plants the county drug task force confiscated in the August 2006 bust of their home.

Rocky Mountain Chronicle
for the rest of the story.

'Cannabis' could help smokers quit

Smokers trying to quit could do so in the future with the help of cannabis-based medicines, a university has said.

Scientists at the University of Nottingham are also looking to see whether such medicines could be used to treat obesity, diabetes and depression.

The research has focused on cannabis-like compounds which naturally exist within the human body called endocannabinoids. Scientists believe they could have a crucial link to addictive behaviour.

Dr Steve Alexander, associate professor at the university's School of Biomedical Sciences, said: "In terms of getting better medicines the endocannabinoid system has a lot to offer.

"The range of cannabis-related medicines is currently limited, but by increasing our knowledge in this area we can increase our stock."

Professor David Kendall, a cellular pharmacologist at the university, said: "The brain is full of cannabinoid receptors.

"And so, not surprisingly with diseases like depression and anxiety, there's a great deal of interest in exploiting these receptors and in doing so, developing anti-depressant compounds.

"We know that the endocannabinoid system is intimately involved in reward pathways and drug-seeking behaviour.

"So this tends to indicate that if the link involving endocannabinoids and the reward pathway, using inhibitors, can be interrupted, it could turn down the drive to seek addictive agents like nicotine."

Cannabinoids have also been shown to bring down blood pressure and it is hoped that related compounds can be used in patients with conditions like hypertension.

The Press Association

Alzheimer's Patients May Benefit From Cannabis-Derived Medicines

LONDON, March 7 /PRNewswire/ -- Cannabis-derived medicines may one day be used in the treatment of Alzheimer's disease which affects 417,000 people in the UK.

Professor Raphael Mechoulam of the Hebrew University of Jerusalem, Israel, will present new findings to a group of international experts at a Cannabinoids Medicines Symposium to be held at the Royal Pharmaceutical Society of Great Britain (RPSGB) in London on Monday, 10 March. The research, still at an early stage, indicates that memory loss, the main symptom of Alzheimer's, can be slowed down significantly in mice by some of the chemicals present in cannabis. The next step will be to initiate human trials to see if the same effect can be achieved on the human brain.

The research is promising for the millions of suffers of the disease and their carers. Alzheimer's disease is the commonest form of dementia, which affects an estimated 24.3 million people worldwide.

It is ten years since the RPSGB launched its protocols to demonstrate the therapeutic effectiveness of cannabis. These protocols led to the Government funded UK trials that looked at the medicinal benefits of cannabis for patients with multiple sclerosis and in the treatment of severe pain. Cannabis-derived medicines have subsequently entered the market and are currently available to patients in Canada.

Professor Tony Moffat, who is chairing the Symposium on Monday said: "We have come a long way in ten years and there is still a lot of research ground to cover. There is currently considerable interest in the medical benefits of cannabis and related compounds for a range of conditions including arthritis, multiple sclerosis and neurological pain. Although recent press coverage has focused on the abuses associated with the plant, cannabis-derived medications may offer novel opportunities in drug discovery."

Notes to editors

About Professor Mechoulam's research

The research was conducted by Professor Raphael Mechoulam of the Hebrew University of Jerusalem, Israel, and a team led by Dr Maria de Ceballos, Cajal Institute, Madrid. In the studies, mice were injected directly into the brain with a molecule found in the human brain of patients suffering from Alzheimer's disease, which is known to be responsible for memory loss. These animals were then treated over a week with cannabidiol. The animals were then assessed as to their learning ability measured by the time needed for them to find a hidden platform in a maze. Mice injected with cannabidiol found the platform within 25-30 seconds, compared to 45-55 seconds of those in a control group who had not been treated with cannabidiol.

UK statistics on Alzheimer's disease

- Alzheimer's disease is the most common form of dementia

- The disease affects around 417,000 people in the UK

Alzheimer's Society http://www.alzheimers.org.uk

Source: Worldwide Statistics on dementia

- Approximately 24.3 million people suffer with dementia

- 4.6 million new cases of dementia are reported every year which equates to one new case every 7 seconds

- The number of people affected with dementia will double every 20 years to 81-1 million by 2040

Source: The Lancet 2005; 366:2112-2117 http://www.thelancet.com/journals/lancet/article/PIIS0140673605678890

About Alzheimer's

People in the early stages of Alzheimer's disease may experience lapses of memory and have problems finding the right words. As the disease progresses they may:

- Become confused, and frequently forget the names of people, places, appointments and recent events

- Experience mood swings. They may feel sad or angry. They may feel scared and frustrated by their increasing memory loss

- Become more withdrawn due either to a loss of confidence or to communication problems

Source: Alzheimer's Society: http://www.alzheimers.org.uk

About the Royal Pharmaceutical Society of Great Britain (RPSGB)

The RPSGB is the professional and regulatory body for pharmacists in England, Scotland and Wales. It also regulates pharmacy technicians on a voluntary basis, which is expected to become statutory under anticipated legislation. The primary objectives of the Society are to lead, regulate, develop and represent the profession of pharmacy. For further information visit http://www.rpsgb.org.
Royal Pharmaceutical Society of GB

Article from The Earth Times

Friday, March 7, 2008

Bipolar medication helps addicts quit cannabis

A COMMON medication used to treat people with bipolar disorder could help cannabis addicts kick the habit without suffering withdrawal symptoms such as aggression and depression, a study has found.

Researchers at Corella Drug Treatment Services and the University of NSW studied 20 people who used cannabis every day for at least nine years, prescribing them 500 milligrams of lithium twice a day for seven days. They found that three months after the treatment most of the users were smoking cannabis less often, and many had given up completely.

Cannabis is the most commonly abused illicit drug in Australia, and the National Drug and Alcohol Research Centre estimates that one in 10 people who try it will become addicted.

Heavy users who try to give up usually experience marked disturbances in mood, sleep and hostility, which can cause them to relapse, making recovery more difficult, but the chief investigator of the study, Adam Winstock, said yesterday that the possibility of finding an effective treatment to manage withdrawal was exciting. "This was a very small trial, and it was carried out in hospital with people who were highly motivated and did not have mental health problems or used other drugs, so it had its limitations, but I'm hoping the results can be matched in a controlled trial next year because we were very impressed with the outcome." Dr Winstock said.

All the participants reported they had been abstinent for an average of 88 per cent of the days since their treatment, and 29 per cent had not used cannabis at all. Studies in rats had shown they experienced an increase in levels of the hormone oxytocin when given lithium during withdrawal from cannabis. Oxytocin is dubbed the "happy hormone" and is released during lactation, orgasm, childbirth, hugging and touching and can produce feelings of wellbeing.

"When the rats were made to go through withdrawal without lithium they appeared to be aggressive and moody, but when they were given lithium they were a little more chilled," Dr Winstock said. "Many people say they smoke a lot of pot because they are depressed, but the truth is that most people in our trial cheered up significantly when they stopped. The bottom line is that quitting can be difficult, but there is help available, and if people do stop smoking pot every day most of them get a lot happier and get a lot more out of their lives," Dr Winstock said.

Sydney Morning Herald

What is wrong with those folks? I am hoping that this is not indicative of the general intelligence level of the entire country.

College Physicians Argue for Legalization of MMJ

Washington -- The idea that marijuana can be good for your health is being supported by a position paper released by the American College of Physicians (ACP), the largest group of internal medicine doctors in the United States.

The paper supports the use of medicinal marijuana as an effective medicine to deal with side effects of chemotherapy treatments and symptoms like HIV-related weight loss and pain from glaucoma.

Tim Kelly, president of the UW chapter of the National Organization for the Reform of Marijuana Laws (NORML), said the federal government has spent too many years ignoring evidence that points toward the medicinal benefits of cannabis.

The federal government claims there is no scientific evidence that says marijuana is useful for those suffering from life threatening diseases, terminal illnesses, or both, Kelly said.

Under federal law marijuana is classified as a Schedule I drug and is grouped with narcotics such as heroin and crystal methamphetamine. Both drugs are highly addictive and neither have been shown to have any medicinal value.

“For too long the federal government, specifically the Drug Enforcement Administration (DEA), has stated that there are no acceptable medical uses of marijuana,” Kelly said.

David C. Dale, a UW professor of internal medicine and the president of ACP, argued for a change in government policy.

“We have recommended that the classification be changed,” he said. cause

To date, Washington is one of 12 states that allow the use of medical marijuana. However, those who are prescribed the drug are not safe from federal prosecution.

ACP believes there should be an exemption from federal prosecution for physicians and pharmacists who prescribe and/or sell medicinal marijuana and for the patients who use it, Dale said. Under the current federal laws an offender can receive up to five years in prison for possessing 100 kilograms of marijuana and up to 10 years for 1,000 kilograms.

Those caught with less than 15 grams of marijuana face paying a fine of $100 or more.

The report released by the ACP is an important step in the movement NORML has been working toward, Kelly said.

“I think the report that the ACP released asking the federal government to lift its restrictions on research and accessibility to medical marijuana is a great tool in our fight for medical marijuana,” he said.

According to the ACP report, research expansion has been hindered by a complicated federal approval process, the limited availability of research-grade marijuana and the debate over legalization.

“The irony to it all is that the DEA severely limits who can legally obtain marijuana for research, causing the problem of little scientific evidence,” Kelly said.

The Daily

Tuesday, March 4, 2008

Czech court supports cannabis grower

Prague- The Czech Supreme Court has upheld a complaint of a woman who had grown cannabis for medical purposes and who had been found guilty of illegal production and possession of drugs by lower level courts and ordered the Prague City Court to deal with her case again.
"The growing of cannabis is not the production of a drug," the court panel headed by Vladimir Jurka said four weeks ago in the verdict that was published on its website now.

Police found 70 plants of cannabis in the woman's vegetable garden. She said she used them to treat her illnesses. She suffered from sole pain and an ulcer and said that her doctor knew that she used cannabis.

The Supreme Court's verdict does not mean legalising cannabis growing. The court stated, however, that the lower level courts should thoroughly prove whether the grower intended to produce marijuana from cannabis or just use it for medical purposes.

The state attorney who supported the woman's complaint said "doctors in the Czech Republic are aware of cannabis medical effects and its use is tolerated if positive results are registered."

In 2005, the Supreme Court issued a verdict that could be interpreted that cannabis growing is legal unlike marijuana production and such interpretations appeared in the media.

The court refuted them and stated that cannabis growing without a permit is illegal since cannabis is a drug.

However, the court said that cannabis growing could not be automatically identified with the production of drugs and courts should thus thoroughly consider the circumstances of each individual case.

ČeskéNoviny.cz


And to think that "Sanity" in the courts comes from the East ... Who-da-thunk? ;)